Superinfection in mice previously infected with Mycobacterium leprae
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چکیده
منابع مشابه
Airborne infection with Mycobacterium leprae in mice.
Although the portal of entry and mode of spread of M. leprae in human leprosy are still uncertain, it is widely held that direct person-to-person skin contact is important. This assumption has ignored the fact that patients with highly bacilliferous leprosy have nasal as well as dermal infection and that, since M. leprae is shed predominantly from the nose, leprosy might be an airborne infectio...
متن کاملResistance to Mycobacterium leprae in Mice Infected with Toxoplasma gondii and Besnoitia jellisoni.
Mice chronically infected with the intracellular protozoan Toxoplasma gondii or Besnoitia jellisoni were resistant to footpad challenge with Mycobacterium leprae. Resistance was manifested by lower numbers of recoverable M. leprae in the footpads of protozoal-infected mice and was enhanced in Toxoplasma-infected mice by a booster injection of Toxoplasma antigen in the infected footpad. The resu...
متن کاملTemperature optimum of Mycobacterium leprae in mice.
Shepard, Charles C. (Communicable Disease Center, Atlanta, Ga.). Temperature optimum of Mycobacterium leprae in mice. J. Bacteriol. 90:1271-1275. 1965.-Mycobacterium leprae multiplied most rapidly in foot pads of mice kept at an air temperature of 20 C. At air temperatures of 15 and 25 C, bacillary multiplication was slightly slower; at 10 and 30 C, distinctly slower; and at 4 and 35 C, no baci...
متن کاملCytokine responses to Mycobacterium leprae unique proteins differentiate between Mycobacterium leprae infected and naive armadillos.
New diagnostic tools for early detection of leprosy are necessary to help reduce its transmission and severity. M. leprae unique proteins have been used to assess differences in human T-cell responses in leprosy patients, household contacts and endemic controls. In this study, we examined the response of M. leprae-infected armadillos to a variety of M. leprae recombinant antigen candidates curr...
متن کاملActivities of various quinolone antibiotics against Mycobacterium leprae in infected mice.
Previously, pefloxacin and ofloxacin were found to be active against Mycobacterium leprae in vitro, in experimental animals, and in clinical trials of lepromatous leprosy patients. In this study, we compared certain more recently developed fluoroquinolones (lomefloxacin, PD 124816, WIN 57273, temafloxacin, and sparfloxacin) with pefloxacin and ofloxacin in M. leprae-infected mice at doses of 50...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1975
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.11.5.1094-1099.1975